Hundreds of English settlers arrive on Roanoke Island, off the coast of present-day North Carolina. Although a previous colony on the island had vanished, Sir Walter Raleigh hopes this second colony will flourish. But three years later, relief ships will find it completely deserted, and the Lost Colony of Roanoke will become a haunting mystery.

Twelve years before Lewis and Clark reach the Pacific, Scottish explorer Alexander Mackenzie finishes a North American cross-continental trip in what will be Canada. Mackenzie will lay the groundwork for Britain’s settlement of Canada and future continent-spanning expeditions further south.

John Dillinger’s seemingly superhuman skill at prison breaks, evading police raids, and literally getting away with murder finally falters as he leaves Chicago’s Biograph Theater. His companion, brothel owner Anna Sage, has set him up and he’s shot while attempting to flee police.